What should you not take with cannabis?
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Marijuana contains the psychoactive cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), and it alters metabolic alterations in a variety of ways. It has the potential to raise the levels or clearing of other drugs while also having considerable consequences. Patients should be warned about the potential effects of cannabinoids. Moreover, in the case of agents metabolized by cytochrome enzymes, clinicians must attempt to prescribe alternative medications.
CBD, as a CYP3A4 substrate, triples tacrolimus serum concentration levels. It does not affect THC levels, nevertheless. Physicians must keep an eye out for negative side effects caused by tacrolimus and use alternative medications whenever possible. Tacrolimus is an oral medication used to treat organ rejection after transplantation. It is used topically to treat skin rashes and atopic dermatitis. Ketoconazole is an azole antifungal medication that is used to relieve severe yeast infections. Mental fogginess and transaminase altitudes are among the augmented CBD effects. Enhanced THC effects may lead to greater psychoactive effects from marijuana. To put it another way, it raises the “high.”
Rifampin, a tuberculin antibiotic, acts as a CYP3A4 inducer, lowering THC concentrations by 20%. The clinical significance of this decrease in THC levels has yet to be determined. Correspondingly, these agents have been shown to reduce CBD levels by 60%. Combined treatment of rifampin with CBD to treat epileptic fits may reduce the efficacy of marijuana. Check out Cannabutter Digest to know more.